Abstract
Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.
MeSH terms
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Bone Morphogenetic Protein 1
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Bone Morphogenetic Proteins / metabolism*
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Chromatography, High Pressure Liquid
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Glutamates / chemical synthesis*
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Glutamates / pharmacology*
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Hydroxamic Acids / chemical synthesis*
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Hydroxamic Acids / pharmacology*
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Indicators and Reagents
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Kinetics
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Matrix Metalloproteinase Inhibitors
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Metalloendopeptidases / metabolism*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology*
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Structure-Activity Relationship
Substances
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Bone Morphogenetic Proteins
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Glutamates
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Hydroxamic Acids
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Indicators and Reagents
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Matrix Metalloproteinase Inhibitors
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Protease Inhibitors
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Metalloendopeptidases
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Bone Morphogenetic Protein 1